In March 2006, Lamborghini unveiled a new version of its halo car at the Geneva Motor Show: the Murciélago LP 640.

With displacement now increased to 6.5 litres, the new car made 640 PS (471 kW; 631 hp) at 8000 rpm. The Murciélago's exterior received a minor facelift. Front and rear fascias were revised, and side air intakes were now asymmetrical with the left side feeding an oil cooler.

A new exhaust, modified suspensions and launch control rounded out the performance modifications.